MISTRG extends PDX modeling to favorable AMLs
نویسندگان
چکیده
منابع مشابه
MISTRG extends PDX modeling to favorable AMLs.
Over the last decade, impressive advances have beenmade inPDXmodeling ofAML. Theengraftment rate forAMLsamples as awhole has been significantly increased through the use of mice that have beenmademore immune deficient by IL2RG knockout and by the transgenic expression of human myelo-supportive cytokines. Nevertheless, the engraftment of samples from favorable-risk patients, including CBF-rearra...
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Targeted therapies have advanced the treatment options for cutaneous melanoma, but many patients will progress on drug. Patient-derived xenografts (PDX) can be used to recapitulate therapy-resistant tumors. Furthermore, PDX modeling can be utilized in combination with targeted sequencing and phosphoproteomic platforms, providing preclinical basis for second-line targeted inhibitor strategies. S...
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ژورنال
عنوان ژورنال: Blood
سال: 2016
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2016-09-738757